Skip to main content
Mijn bibliotheek
Shop
Nieuws Boeken Tijdschriften Toetsvragen Web-tv Video Audio
Tips voor Mijn BSL
Inloggen

Welkom bij Scalda & Bohn Stafleu van Loghum

Scalda heeft ervoor gezorgd dat je Mijn BSL eenvoudig en snel kunt raadplegen.Je kunt de producten hieronder links aanschaffen en rechts inloggen.

» Andere revante producten voor Scalda studenten en medewerkers.

Registreer

Schaf de BSL Academy aan: 

BSL Academy mbo AG

Eenmaal aangeschaft kun je thuis, of waar ook ter wereld toegang krijgen tot Mijn BSL.

Heb je een vraag, neem dan contact op met Jan van der Velden.

Login

Als u al geregistreerd bent, hoeft u alleen maar in te loggen om onbeperkt toegang te krijgen tot Mijn BSL.

Inloggen
Top
Journal of Behavioral Medicine
Gepubliceerd in:

01-04-2006 | Original Article

Anger Regulation Style, Postoperative Pain, and Relationship to the A118G Mu Opioid Receptor Gene Polymorphism: A Preliminary Study

Auteurs: Stephen Bruehl, Ok Y. Chung, Brian S. Donahue, John W. Burns

Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 2/2006

Log in om toegang te krijgen
share
DELEN

Deel dit onderdeel of sectie (kopieer de link)

  • Optie A:
    Klik op de rechtermuisknop op de link en selecteer de optie “linkadres kopiëren”
  • Optie B:
    Deel de link per e-mail
    Link delen
publish
Publiceer nu

Abstract

Greater trait anger-out is associated with elevated pain responsiveness. Previous work suggests this effect may be mediated by deficient endogenous opioid analgesia, possibly reflecting diminished opioid receptor sensitivity. The A118G single nucleotide polymorphism (SNP) of the mu opioid receptor gene influences both opioid receptor sensitivity and clinical responsiveness to opioid analgesics. Therefore, this study tested whether this SNP either mediated or moderated the effects of anger-out on postsurgical pain outcomes. Forty-eight patients undergoing coronary artery bypass graft surgery provided genetic samples, and completed measures of anger-out and postsurgical pain. Postsurgical opioid analgesic use was also recorded. Anger-out was positively associated with postsurgical pain ratings (p < 0.05). Anger-out was not associated with A118G SNP status (p > 0.10), suggesting the latter is unlikely to mediate anger-out's pain-related effects. A significant anger-out × A118G interaction was observed on analgesic use (p < 0.05), due to a much stronger positive relationship between anger-out and analgesic demands in patient with the A118G SNP (b = 0.53) than those with the wild-type receptor (b = 0.07). These results suggest that the A118G SNP may moderate but not mediate the effects of anger-out on postoperative pain responses.
vorige artikel Psychological Symptoms Following Smoking Cessation in Pregnant Smokers
volgende artikel Expectations and Placebo Response: A Laboratory Investigation into the Role of Somatic Focus
Literatuur
Aiken, L. S., and West, S. G. (1991). Multiple Regression: Testing and Interpreting Interactions, Sage, Thousand Oaks, CA.
Baron, R. M., and Kenny, D. A. (1986). The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J. Pers. Soc. Psych. 51: 1173–1182.CrossRef
Bond, C., LaForge, K. S., Tian, M., Melia, D., Zhang, S., Borg, L., Gong, J., Schluger, J., Strong, J. A., Leal, S. M., Tischfield, J. A., Kreek, M. J., and Yu, L. (1998). Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proc. Natl. Acad. Sci. U.S.A. 95: 9608–9613.PubMedCrossRef
Bouchard, T. J., and Loehlin, J. C. (2001). Genes, evolution, and personality. Behav. Genet. 31: 243–273.CrossRefPubMed
Bruehl, S., Burns, J. W., Chung, O. Y., Ward, P., and Johnson, B. (2002). Anger and pain sensitivity in chronic low back pain patients and pain-free controls: The role of endogenous opioids. Pain 99: 223–233.CrossRefPubMed
Bruehl, S., Chung, O. Y., Burns, J. W., and Biridepalli, S. (2003). The association between anger expression and chronic pain intensity: Evidence for partial mediation by endogenous opioid dysfunction. Pain 106: 317–324.CrossRefPubMed
Burns, J. W., and Bruehl, S. (in press). Anger management style, opioid analgesic use, and chronic pain severity: A test of the opioid-deficit hypothesis. J. Behav. Med.
Burns, J. W., Bruehl, S., and Caceres, C. (2004). Anger management style, blood pressure reactivity and acute pain sensitivity: Evidence for a Trait × Situation model. Ann. Behav. Med. 27: 195–204.CrossRefPubMed
Burns, J. W., Johnson, B. J., Devine, J., Mahoney, N., and Pawl, R. (1998). Anger manger management style and prediction of treatment outcome among male and female chronic pain patients. Behav. Res. Ther. 36: 1051–1062.CrossRefPubMed
Caraco, Y., Maroz, Y., and Davidson, E. (2001). Variability in alfentanil analgesia may be attributed to polymorphism in the mu opioid receptor (abstract). Clin. Pharmacol Ther. 69: p63/OII-A-4.
Casey, K. L., Svensson, P., Morrow, T. J., Raz, J., Jone, C., and Minoshima, S. (2000). Selective opiate modulation of nociceptive processing in the human brain. J. Neurophysiol. 84: 525–533.PubMed
Chou, W. Y., and Hsu, C. J. (2004). Genotype influences the effect of patient-controlled analgesics in patients after knee arthroplasty (abstract). In Proceedings of the 71st annual meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA.
Comings, D. E., Johnson, J. P., Gonzalez, N. S., Huss, M., Saucier, G., McGue, M., and MacMurray, J. (2000). Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity, and memory in normal subjects. Psychiatr. Genet. 10: 39–42.PubMedCrossRef
Davidson, R. J., Putnam, K. M., and Larson, C. L. (2000). Dysfunction in the neural circuitry of emotion regulation—A possible prelude to violence. Science 289: 591–594.CrossRefPubMed
Dougherty, D. D., Shin, L. M., Alpert, N. M., Pitman, R. K., Orr, S. P., Laska, M., Macklin, M. L., Fischman, A. J., and Rach, S. L. (1999). Anger in healthy men: A PET study using script-driven imagery. Biol. Psychiatry 46: 466–472.CrossRefPubMed
Fillingim, R. B., Kaplan, L., Staud, R., Ness, T. J., Glover, T. L., Campbell, C. M., Mogil, J. S., Wallace, M. R. (2005). The A118G single nucleotide polymorphism of the mu-opioid receptor gene (OPRM1) is associated with pressure pain sensitivity in humans. J. Pain 6: 159–167.CrossRefPubMed
Gelernter, J., Kranzler, H., and Cubells, J. (1999). Genetics of two mu opioid receptor gene (OPRM1) exon I polymorphisms: Population studies, and allele frequencies in alcohol- and drug-dependent subjects. Mol. Psych. 4: 476–483.CrossRef
Gelkopf, M. (1997). Laboratory pain and styles of coping with anger. J. Psychol. 131: 121–123.PubMed
Hirota, T., Ieiri, I., Takane, H., Sano, H., Kawamoto, K., Aono, H., Yamasaki, A., Takeuchi, H., Masada, M., Shimizu, E., Higuchi, S., and Otsubo, K. (2003). Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy. Drug Metab. Dispos. 31: 677–680.CrossRefPubMed
Keefe, F. J., Lumley, M., Anderson, T., Lynch, T., and Carson, K. L. (2001). Pain and emotion: New research directions. J. Clin. Psychol. 57: 587–607.CrossRefPubMed
Kerns, R. D., Rosenberg, R., and Jacob, M. C. (1994). Anger expression and chronic pain. J. Behav. Med. 17: 57–67.CrossRefPubMed
Klepstad, P., Rakvag, T. T., Kaasa, S., Holthe, M., Dale, O., Borchgrevink, P. C., Baar, C., Vikan, T., Krokan, H. E., and Skorpen, F. (2004). The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease. Acta. Anaesthesiol. Scand. 48: 1232–1239.CrossRefPubMed
Lotsch, J., Skarke, C., Grosch, S., Darimont, J., Schmidt, H., and Geisslinger, G. (2002). The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine. Pharmacogenetics 12: 3–9.CrossRefPubMed
Lotsch, J., Skarke, C., Liefhold, J., and Geisslinger, G. (2004). Genetic predictors of the clinical response to opioid analgesics: Clinical utility and future perspectives. Clin. Pharmacokinet. 43: 983–1013.PubMedCrossRef
Manuck, S. B., Flory, J. D., Ferrell, R. E., Dent, K. M., Mann, J. J., and Muldoon, M. F. (1999). Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol. Psychiatry 45: 603–614.CrossRefPubMed
Materazzo, F., Cathart, S., and Pritchard, D. (2000). Anger, depression, and coping interactions in headache activity and adjustment: A controlled study. J. Psychosom. Res. 49: 69–75.CrossRefPubMed
Mormede, P., Courvoisier, H., Ramos, A., Marissal-Arvy, N., Ousova, O., Desautes, C., Duclos, M., Chaouloff, F., and Moisan, M. P. (2002). Molecular genetic approaches to investigate individual variations in behavioral and neuroendocrine stress responses. Psychoneuroendocrin 27: 563–583.CrossRef
Price, D. D. (2000). Psychological and neural mechanisms of the affective dimension of pain. Science 288: 1769–1772.CrossRefPubMed
Sayar, K., Gulec, H., and Topbas, M. (2004). Alexithymia and anger in patients with fibromyalgia. Clin. Rheumatol. 23: 441–448.CrossRefPubMed
Schlaepfer, T. E., Strain, E. C., Greenberg, B. D., Preston, K. L., Lancaster, E., Bigelow, G. E., Barta, P. E., and Pearlson, G. D. (1998). Am. J. Psychiatry 155: 470–473.PubMed
Spielberger, C. D., Johnson, E. H., Russell, S. F., Crane, R. J., Jacobs, G. A., and Worden, T. J. (1985). The experience and expression of anger: Construction and validation of an anger expression scale. In M. A. Chesney, and R. H. Rosenman, (Eds.), Anger and Hostility in Cardiovascular and Behavioral Disorders, Hemisphere, Washington, DC, pp. 5–30.
Metagegevens
Titel
Anger Regulation Style, Postoperative Pain, and Relationship to the A118G Mu Opioid Receptor Gene Polymorphism: A Preliminary Study
Auteurs
Stephen Bruehl
Ok Y. Chung
Brian S. Donahue
John W. Burns
Publicatiedatum
01-04-2006
Uitgeverij
Springer US
Gepubliceerd in
Journal of Behavioral Medicine / Uitgave 2/2006
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521
DOI
https://doi.org/10.1007/s10865-005-9030-7

Andere artikelen Uitgave 2/2006

Effects of Cognitive Adaptation on the Expectation-Burnout Relationship Among Nurses1

Factors Affecting Hospital Staff Judgments About Sickle Cell Disease Pain

  • Original Article

Predictors of Positive Psychosocial Functioning of Older Adults in Residential Care Facilities

  • Original Research

Sleep Disruptions Mediate the Relationship Between Early Postoperative Pain and Later Functioning Following Total Knee Replacement Surgery

Associations Among Health Behaviors and Time Perspective in Young Adults: Model Testing with Boot-Strapping Replication

Psychological Symptoms Following Smoking Cessation in Pregnant Smokers