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Gepubliceerd in:
18-05-2024
Childhood adversity, accelerated GrimAge, and associated health consequences
Auteurs: Zachary M. Harvanek, Anastacia Y. Kudinova, Samantha A. Wong, Ke Xu, Leslie Brick, Teresa E. Daniels, Carmen Marsit, Amber Burt, Rajita Sinha, Audrey R. Tyrka
Gepubliceerd in: Journal of Behavioral Medicine | Uitgave 5/2024
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Abstract
Childhood adversity is linked to psychological, behavioral, and physical health problems, including obesity and cardiometabolic disease. Epigenetic alterations are one pathway through which the effects of early life stress and adversity might persist into adulthood. Epigenetic mechanisms have also been proposed to explain why cardiometabolic health can vary greatly between individuals with similar Body Mass Index (BMIs). We evaluated two independent cross-sectional cohorts of adults without known medical illness, one of which explicitly recruited individuals with early life stress (ELS) and control participants (n = 195), and the other a general community sample (n = 477). In these cohorts, we examine associations between childhood adversity, epigenetic aging, and metabolic health. Childhood adversity was associated with increased GrimAge Acceleration (GAA) in both cohorts, both utilizing a dichotomous yes/no classification (both p < 0.01) as well as a continuous measure using the Childhood Trauma Questionnaire (CTQ) (both p < 0.05). Further investigation demonstrated that CTQ subscales for physical and sexual abuse (both p < 0.05) were associated with increased GAA in both cohorts, whereas physical and emotional neglect were not. In both cohorts, higher CTQ was also associated with higher BMI and increased insulin resistance (both p < 0.05). Finally, we demonstrate a moderating effect of BMI on the relationship between GAA and insulin resistance where GAA correlated with insulin resistance specifically at higher BMIs. These results, which were largely replicated between two independent cohorts, suggest that interactions between epigenetics, obesity, and metabolic health may be important mechanisms through which childhood adversity contributes to long-term physical and metabolic health effects.
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Metagegevens
- Titel
- Childhood adversity, accelerated GrimAge, and associated health consequences
- Auteurs
-
Zachary M. Harvanek
Anastacia Y. Kudinova
Samantha A. Wong
Ke Xu
Leslie Brick
Teresa E. Daniels
Carmen Marsit
Amber Burt
Rajita Sinha
Audrey R. Tyrka
- Publicatiedatum
- 18-05-2024
- Uitgeverij
- Springer US
- Gepubliceerd in
-
Journal of Behavioral Medicine
/ Uitgave 5/2024
Print ISSN: 0160-7715
Elektronisch ISSN: 1573-3521 - DOI
- https://doi.org/10.1007/s10865-024-00496-0
