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01-06-2012 | Extent of nodal dissection in robot assisted laparoscopic prostatectomy and functional recovery

Extent of nodal dissection in robot assisted laparoscopic prostatectomy and functional recovery

Auteurs: dr. H. G. van der Poel, C. Tillier, W. de Blok, H. M. van Muilekom

Gepubliceerd in: Tijdschrift voor Urologie | Uitgave 4/2012

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Samenvatting

 

Uitgebreidere pelviene klierdissectie is gerelateerd aan verminderd seksueel functieherstel na prostatectomie

Doel:

Richtlijnen adviseren een uitgebreide klierdissectie bij patiënten met een verhoogd risico op kliermetastasen tijdens een prostatectomie. Hierbij dienen ook de klieren in de regio iliaca interna te worden verwijderd. Aangezien deze klieren dicht bij de hypogastrische zenuwplexus liggen, onderzochten wij de invloed van meer uitgebreide klierdissectie op seksueel functieherstel na robotgeassisteerde laparoscopische prostatectomie (RALP).

Methode:

In een serie van 798 RALP-procedures, ondergingen 325 (40,7%) patiënten een lymfeklierdissectie. Continentie en seksuele functie worden voor en na de ingreep geëvalueerd met de ICIQ-SF- en IIEF-15-vragenlijsten.

Resultaten:

Gemiddelde ICIQ-SF- en IIEF-15-scores voor de ingreep waren gelijk bij mannen met en zonder een klierdissectie. Een normale preoperatieve erectiele functie (IIEF-EF > 20) werd gevonden bij 29,6% van de mannen. Een bilaterale of unilaterale zenuwsparing werd uitgevoerd bij 38,8% en 30,8% van de mannen. Normale postoperatieve erectiele functie na 6 maanden werd gerapporteerd door 1,7%, 9,1%, en 50,4% van de mannen zonder of met unilaterale of bilaterale zenuwsparing en normale preoperatieve erectiele functie.
Bij 70 van 325 (21%) patiënten met een klierdissectie werden meer dan 10 klieren verwijderd. Kliermetastasen werden gevonden bij 5,9% en 15,7% van de patiënten bij wie £ 10 klieren en > 10 klieren werden verwijderd (p = 0,005). Alle domeinen van de IIEF-15-score 6 maanden na RALP waren negatief gecorreleerd met het aantal verwijderde lymfeklieren. In een multivariate analyse waren de volgende onafhankelijke variabelen gecorreleerd met IIEF-EF-score: fascia preservatiescore (FP-score), preoperatieve IIEF-EF-score en het aantal verwijderde lymfeklieren.

Conclusie:

Een meer uitgebreide klierdissectie was geassocieerd met een hoger percentage positieve klieren en een verminderd herstel van de seksuele functies; dit gold niet voor continentie na RALP.
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Metagegevens
Titel
Extent of nodal dissection in robot assisted laparoscopic prostatectomy and functional recovery
Auteurs
dr. H. G. van der Poel
C. Tillier
W. de Blok
H. M. van Muilekom
Publicatiedatum
01-06-2012
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Tijdschrift voor Urologie / Uitgave 4/2012
Print ISSN: 2211-3037
Elektronisch ISSN: 2211-4718
DOI
https://doi.org/10.1007/s13629-012-0057-6