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22-06-2024

Health-related quality of life and radioiodine therapy in thyroid cancer patients: a before-and-after study

Auteurs: Alix Legrand, Marie-Odile Bernier, Alice Bressand, Camille Buffet, Corinne Mandin, Fabrice Menegaux, Marine Soret, David Broggio, Céline Bassinet, Christelle Huet, Laurence Leenhardt, Charlotte Lussey-Lepoutre, Clémence Baudin

Gepubliceerd in: Quality of Life Research | Uitgave 10/2024

Abstract

Objective

Thyroid cancers are on the rise, but the associated vital prognosis and long-term survival rates are very good. Therefore, treated patients’ quality of life and psychological well-being are important considerations. The treatment usually involves surgery and radioactive iodine (radioiodine) ablation. This study aims to investigate potential effects of radioiodine ablation therapy on health-related quality of life, anxiety and depression symptoms, and nutritional status at 6 months post-therapy.

Methods

This study included 136 patients diagnosed with thyroid cancer. Absorbed doses to the salivary glands were estimated from dosimeters worn by patients. Patient health-related quality of life, psychological status and nutritional status were assessed before and 6 months after therapy using standardized questionnaires (including SF-36, Hospital Anxiety and Depression (HAD) scale). Statistical analyses included random-effects logistic and linear regressions adjusted for potential confounders.

Results

While no significant association was found between radioiodine exposure and anxiety or depression symptoms, or nutritional status, a significant increase in the SF-36 role physical sub- score was observed in relation with the salivary gland dose (β= 6.54, 95%CI 2.71;10.36 for a 1-Gy increase).

Conclusions

The findings suggest an improved physical health-related quality of life, namely reduced pain and functional impairment, 6 months after radioiodine therapy in thyroid cancer patients. No significant association was found between radioiodine exposure and mental health-related quality of life, anxiety or depression scores nor nutritional status. This study does not provide any evidence that radioiodine therapy has a potentially adverse effect on patient health-related quality of life.

vorige artikel Health-related quality of life in ethnically diverse Black prostate cancer survivors: a convergent parallel mixed-methods approach

volgende artikel A longitudinal study of within-person trajectories in quality of life in patients receiving early palliative care

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Titel: Health-related quality of life and radioiodine therapy in thyroid cancer patients: a before-and-after study
Auteurs: Alix Legrand
Marie-Odile Bernier
Alice Bressand
Camille Buffet
Corinne Mandin
Fabrice Menegaux
Marine Soret
David Broggio
Céline Bassinet
Christelle Huet
Laurence Leenhardt
Charlotte Lussey-Lepoutre
Clémence Baudin
Publicatiedatum: 22-06-2024
Uitgeverij: Springer International Publishing
Gepubliceerd in: Quality of Life Research / Uitgave 10/2024
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI: https://doi.org/10.1007/s11136-024-03721-0

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Health-related quality of life and radioiodine therapy in thyroid cancer patients: a before-and-after study

Abstract

Objective

Methods

Results

Conclusions

Andere artikelen Uitgave 10/2024

Measuring what matters to older persons for active living: part I content development for the OPAL measure across four countries

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Bohn Stafleu van Loghum

Welkom bij Scalda & Bohn Stafleu van Loghum

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Abstract

Objective

Methods

Results

Conclusions

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Measuring what matters to older persons for active living: part I content development for the OPAL measure across four countries

Analyzing quality of life among people with opioid use disorder from the National Institute on Drug Abuse Data Share initiative: implications for decision making

Requirements on construction methods for MID values should be fulfilled for at least one method

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