Sleep is an essential pillar of health and is vital for day-to-day functioning and life. According to the Center for Disease Control and Prevention, 1 in 3 adults in the general public report not getting enough sleep. A single night of inadequate …

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory and neurodegenerative disease that affected approximately 2.8 million people globally in 2020 [ 1 ]. It presents with a range of central nervous system dysfunctions, leading to diverse …

Fatigue–a perceived lack of energy, tiredness, and/or exhaustion—is a common and impactful symptom across nearly every health condition [ 1 ], and is a cardinal characteristic of conditions such as multiple sclerosis (MS) [ 2 , 3 ] and fibromyalgia …

Mental disorders, also known as mental illnesses, are conditions that affect a person's thinking, mood, behavior, or overall sense of well-being. They affect 1 in 5 adults in the United States (U.S.) and cost approximately $280 billion dollars …

Systematic measurement of children’s health-related quality of life (HRQoL) and related constructs via patient reported outcome measures (PROMs) is essential for incorporating children’s own views and experiences into healthcare, research and …

The inclusion of health-related quality of life (HRQoL) impacts on informal carers in health technology assessments (HTAs) is lacking due, primarily, to a deficiency in evidence and methodological issues on how informal carer HRQoL is captured and …

Pouch surgery is performed to improve the quality of life of patients who have had their colon and rectum removed by avoiding a permanent stoma. Pouch-related fistulae are complications of pouch surgery that are difficult to treat, with limited …

Wellbeing and health-related quality of life (HRQoL) are important parts of positive child development and health [ 1 ]. Poor wellbeing among children and youth is an increasing concern worldwide [ 2 ], and in Denmark, a decrease in wellbeing has …

The hepatitis C virus (HCV) has a dramatic global impact, with an estimated 50 million people with chronical infection by 2022 and about 1.5 million new infections occurring annually [ 1 ]. While some people with HCV may be asymptomatic, others may …

Health Technology Assessment (HTA) is a crucial component of healthcare systems, essential for prioritizing interventions and allocating resources effectively [ 1 ]. It involves the systematic evaluation of health technologies, providing …

Healthcare systems are facing the challenge of an ageing population, increased rates of chronic disease and rising healthcare costs [ 1 – 3 ]. This challenge is likely to escalate, with the global number of people aged 60 years and over projected …

Few health-related constructs or measures have received a critical evaluation in terms of measurement equivalence, such as self-reported health survey data. Differential item functioning (DIF) analysis is crucial for evaluating measurement …

Health-related quality of life (HRQoL) is a multidimensional concept that encompasses the physical, mental, and social aspects of health [ 1 ]. Lower HRQoL levels, closely associated with increased risks of conditions like obesity/overweight …

In this review, we explore the instructions provided to informal carers (‘proxies’) completing questionnaires for individuals who are unable to complete questionnaires. By understanding these instructions, informal carers can provide useful …

Irritable bowel syndrome (IBS) affects 10–15% of the global population [ 1 ]. It is a functional gastrointestinal disorder characterized by abdominal pain, bloating, and altered bowel habits. These symptoms significantly affect patients’ quality of …

Patients with cancer worldwide often face considerable financial burdens [ 1 ]. The experienced financial challenges can adversely impact their financial well-being, which is the perceived ability to sustain living standards and achieve financial …

Adolescents and young adults (AYAs) are defined as individuals aged between 15 and 39 years at the time of their initial cancer diagnosis, according to the US National Cancer Institute [ 1 ]. However, the AYA age range may be defined differently in …

This study employed a well-established methodology, as described by Kisala and Tulsky [ 42 ], for identifying important HRQOL topics for rehabilitation populations, which utilizes open-ended and free-flowing discussion of the experiences of …

Thresholds for meaningful within-individual change (MWIC) are crucial for interpreting patient-reported outcomes (PRO) data and evaluating treatment benefits. Traditional methods for determining MWIC threshold can be biased, especially when the …