Abstract
The study examined the association between low birth weight (LBW) (≤2,500 g) and attention deficit hyperactivity disorder (ADHD) in two socioeconomically disparate populations. LBW and normal birth weight (NBW) children from the 1983 to 1985 newborn lists of an urban and a suburban hospital in Southeast Michigan were randomly selected. A total of 823 children, 473 LBW and 350 NBW, participated. Data were gathered in 1990 to 1992, when the children were 6 to 7 years of age. The National Institute of Mental Health Diagnostic Interview Schedule for children—Parent version (DISC-P) was used to elicit information on DSM-III-R diagnoses of simple phobia, overanxious, separation anxiety, oppositional defiant, and ADHD. Teachers' ratings of behavior problems were obtained. LBW was associated with ADHD but not with childhood anxiety disorders or oppositional defiant disorder. The association was stronger in the urban than in the suburban population. Data from teachers' ratings revealed an association between LBW and attention problems. The prognostic significance of the observed psychopathology at 6 years of age requires follow-up assessment as the children mature.
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.References
Achenbach, T. M. (1991).Teacher's Report Form. Burlington, VT: Center for Children, Youth and Families.
Achenbach, T. M., & Edelbrock, C. (1991).Manual for the Child Behavior Checklist. Queen City Printers, Inc.
American Psychiatric Association (1987).Diagnostic and statistical manual of mental disorders (3rd ed., rev.). Washington, DC: Author.
Breslau, N. (1985). Psychiatric disorder in children with physical disabilities.Journal of the American Academy of Child Psychiatry, 24 87–94.
Breslau, N. (1990). Does brain dysfunction increase children's vulnerability to environmental stress?Archives of General Psychiatry, 47 15–20.
Breslau, N., DelDotto, J. E., Brown, G. C., Kumar, S., Ezhuthachan, S., Hufnagle, K. G., & Peterson, E. L. (1994). A gradient relationship between low birth weight and IQ at 6 years.Archives of Pediatric and Adolescent Medicine, 148 377–383.
Breslow, N. E., & Day, N. E. (1980).Statistical methods in cancer research, Volume 1: The analysis of case-control studies. Lyon: International Agency for Research on Cancer.
Buka, S. L., Lipsitt, L. P., & Tsuang, M. T. (1992). Emotional and behavioral development of low-birthweight infants. In S. L. Friedman & M. D. Sigman (Eds.),The psychological development of low-birthweight children: Annual advances in applied developmental psychology (Vol. 6, pp. 187–214). Norwood, NY: Ablex.
Costello, A. J., Edelbrock, C., Dulcan, M. K., Kalas, R., & Klaric, S. H. (1984).The National Institute of Mental Health Diagnostic Interview Schedule for Children (DISC): Final Report. Rockville, MD: National Institute of Mental Health.
Dunn, H. G., H. H. H., & Schulzer, M. (1986). Minimal brain dysfunctions. In H. G. Dunn (Ed.),Sequelae of Low Birthweight: The Vancouver Study. Oxford, England. MacKeith Press.
Ellis, W. G., Goetzman, B. W., & Lindenberg, J. A. (1988). Neuropathologic documentation of prenatal brain damage.American Journal of Diseases of Children, 142 858–866.
Escalona, S. K. (1982). Babies at double hazard: Early development in infants at biologic and social risk.Pediatrics, 70 670–676.
Fuller, P. W., Guthrie, R. D., Alvord, E. C. (1983). A proposed neuropathological basis for learning disabilities in children born prematurely.Developmental Medicine and Child Neurology, 25 214–231.
Goodman, R., & Stevenson, J. (1989). A twin study of hyperactivity II: The aetiological role of genes, family relationships and perinatal adversity.Journal of Child Psychology and Psychiatry, 30 691–709.
Grunnet, M. L., Curless, R. G., Bray, P. F., & Jung, A. L. (1974). Brain changes in newborns from an intensive care unit.Developmental Medicine and Child Neurology, 16 320–328.
Hack, M., Breslau, N., Aram, D., Weissman, B., Klein, N., & Borawski-Clark, E. (1992). The effect of very low birth weight and social risk on neurocognitive abilities at school age.Journal of Developmental and Behavioral Pediatrics, 13 412–420.
Hack, M., Breslau, N., Weissman, B., Aram, D., Klein, N., & Borawski, E. (1991). Effect of very low birth weight and subnormal head size on cognitive abilities at school age.New England Journal of Medicine, 325 231–237.
Kleinbaum, D. V., Kupper, L. L., Morgenstern, H. (1982).Epidemiologic research: Principles and quantitative methods. New York: Van Nostrand Reinhold.
Kramer, M. S. (1987). Determinants of low birthweight: Methodological assessment and metaanalysis.Bulletin of the World Health Organization, 65 663–737.
Leech, R. W., & Alvord, E. C., Jr. (1974). Perinatal leukoencephalopathy, an expanded concept.Journal of Neuropathology and Experimental Neurology, 33 568–569.
Levy-Shiff, R., Einat, G., Mogilner, M. B., Lerman, M., & Krikler, R. (1994). Biological and environmental correlates of developmental outcome of prematurely born infants in early adolescence.Journal of Pediatric Psychology, 19 63–78.
Marlow, N., Roberts, B. L., & Cooke, R. W. I. (1989). Motor skills in extremely low birthweight children at the age of 6 years.Archives of Disease in Childhood, 64 839–847.
McCormick, M. C., Brooks-Gunn, J., Workman-Daniels, K., Turner, J., & Peckham, G. J. (1992). The health and developmental status of very low-birth-weight children at school age.Journal of the American Medical Association, 267 2204–2208.
McCormick, M. C., Gortmaker, S. L., & Sobol, A. M. (1990). Very low birth weight children: Behavior problems and school difficulty in a national sample.Journal of Pediatrics, 117 686–693.
McGauhey, P. J., Staffield, B. H., Alexander, C., & Ensminger, M. E. (1991). Social environment and vulnerability of low birth weight children: A social-epidemiological perspective.Pediatrics, 88 943–953.
Pasamanick, B., & Knobloch, H. (1961). Epidemiologic studies on the complications of pregnancy and the birth process. In G. Caplan (Ed.),Prevention of Mental Disorders in Children (pp. 74–94). New York: Basic Books.
Pasamanick, B., & Lilienfeld, A. M. (1955). Association of maternal and fetal factors with development of mental deficiency: Abnormalities in the prenatal and perinatal periods.Journal of the American Medical Association, 159 155–160.
Pasamanick, B., Rogers, M. E., & Lilienfeld, A. M. (1956). Pregnancy experience and the development of behavior disorder in children.American Journal of Psychiatry, 112 613–618.
Peterson, M. B., Greisen, G., Kovacs, R., Munck, H., & Friis-Hansen, B. (1990). Status at four years of age in 280 children weighing 2,300 g or less at birth.Danish Medical Bulletin, 37 546–552.
Robins, L., Helzer, J., Cottler, L., & Golding, E. (1989).The NIMH Diagnostic Interview Schedule, Version III, Revised. St. Louis, MO: Washington University.
Saigal, S., Szatmari, P., Rosenbaum, P., Campbell, D., & King, S. (1991). Cognitive abilities and school performance of extremely low birth weight children and matched term control children at age 8 years: A regional study.Journal of Pediatrics, 118 751–760.
Sameroff, A. J., & Chandler, M. (1975). Reproductive risk and the continuum of caretaking casualty. In F. D. Horowitz, M. Hetherington, S. Scarr-Salapatek, & G. Siegel (Eds.),Review of Child Development Research (Vol. 4). Chicago: University of Chicago Press.
Schwab-Stone, M., Fallon, T., Briggs, M., & Crowther, B. (1994). Reliability of diagnostic reporting for children 6–11 years: A test-retest study of the revised Diagnostic Interview Schedule for Children.American Journal of Psychiatry, 151 1048–1054.
Shaffer, D., Schwab-Stone, M., Fisher, P., Davies, M., Piacentini, J., & Gioia, P. (1988).A revised version of the Diagnostic Interview Schedule for Children (DISC-R): Results of a field trial and proposals for a new instrument (DISC-2). Rockville, MD: Epidemiology and Psychopathology Research Branch, Division of Clinical Research, National Institute of Mental Health.
Silverstein, A. B. (1982), Two- and four-subtest short forms of the Wechsler Adult Intelligence Scale—Revised.Journal of Consulting and Clinical Psychology, 50 425–418.
Sprich-Buckminster, S., Biederman, J., Milberger, S., Faraone, S. V., & Lehman, B. K. (1993). Are perinatal complications relevant to the manifestation of ADD? Issues of comorbidity and familiality.Journal of the American Academy of Child and Adolescent Psychiatry, 32 1032–1037.
Szatmari, P., Saigal, S., Rosenbaum, P., Campbell, D., & King, S. (1990). Psychiatric disorders at five years among children with birth weights <1000 g: A regional perspective.Developmental Medicine and Child Neurology, 32 954–962.
Takashima, S., Becker, L. E., Chan, F. (1982). Retardation of neuronal maturation in premature infants compared with term infants of the same post-conceptional age.Pediatrics, 69 33–39.
Teplin, S. W., Burchinal, M., Johnson-Martin, N., Humphry, R. A., & Kraybill, E. N. (1991). Neurodevelopmental, health, and growth status at age 6 years of children with birth weights less than 1001 grams.Journal of Pediatrics, 11 768–777.
The Scottish Low Birthweight Study Group. (1992). The Scottish low birthweight study: II. Language attainment, cognitive status, and behavioral problems.Archives of Disease in Childhood, 67 682–686.
Trompeter, R. S., Dobbing, J., Aynsley-Green, A., & Baum, J. D. (1976). Neonatal brain growth during prolonged intravenous feeding.Archives of Disease in Childhood, 51 316–318.
Wechsler, D. (1974).Wechsler Intelligence Scale for Children—Revised. New York: Psychological Corporation.
Weinberg, C. R. (1993). Toward a clearer definition of confounding.American Journal of Epidemiology, 137 1–8.
Werner, E. E., Bierman, J. M., & French, F. E. (1971).The Children of Kauai: A longitudinal study from the prenatal period to age ten. Honolulu: University of Hawaii Press.
Werner, E. E., & Smith, R. S. (1982).Vulnerable, but invincible: A longitudinal study of resilient children and youth. New York: McGraw-Hill.
Author information
Authors and Affiliations
Additional information
This research was supported by NIMH research grant MH-44586 and NIMH Research Scientist Development Award MH-00380 to Dr. Breslau.
Rights and permissions
About this article
Cite this article
Breslau, N., Brown, G.G., DelDotto, J.E. et al. Psychiatric sequelae of low birth weight at 6 years of age. J Abnorm Child Psychol 24, 385–400 (1996). https://doi.org/10.1007/BF01441637
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01441637