The aim of this study was to examine the association between mindfulness training and restrictive interventions implemented by staff employed in two residential service homes who supported people with a disability who showed severe challenging behavior. Twelve disability support workers completed an 8-week group-based mindfulness training program in February to March 2010. Pro re nata (PRN, as required) and emergency seclusions and chemical restraints reported for the homes during the 2 months of the training program and the 3 months following the program (February to June 2010) were compared to those for the corresponding months in 2009. Compared to the number of PRN and emergency seclusions and PRN and emergency chemical restraints for the two homes for February to June 2009, those for February to June 2010 were significantly lower. Mindfulness training may have helped staff to respond to clients’ challenging behaviors in a more mindful and less reactive way.