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Gepubliceerd in:

01-12-2008 | case report

Pregnancy and the risk of torsades de pointes in congenital long-QT syndrome

Auteurs: P. G. Meregalli, I. C. D. Westendorp, H. L. Tan, P. Elsman, W. E. M. Kok, A. A. M. Wilde

Gepubliceerd in: Netherlands Heart Journal | Uitgave 12/2008

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Extract

Long-QT syndrome (LQTS) is an electrical disorder of myocardial repolarisation characterised by a prolonged QT interval and associated with sudden cardiac death.1 It can be congenital, acquired or a combination of both. The prevalence of congenital LQTS is estimated at around 1:2000 and it is believed that congenital forms account for 3000 deaths of young people per year in the USA.2 Syncope and sudden death occur because of polymorphic ventricular tachycardia (VT) with specific features, known as torsades de pointes.3
Literatuur
1.
go back to reference Schwartz PJ, Moss AJ, Vincent GM, Crampton RS. Diagnostic criteria for the long QT syndrome. An update. Circulation 1993;88:782-4. Schwartz PJ, Moss AJ, Vincent GM, Crampton RS. Diagnostic criteria for the long QT syndrome. An update. Circulation 1993;88:782-4.
2.
go back to reference Roden DM. Clinical practice. Long-QT syndrome. N Engl J Med 2008;358:169-76. Roden DM. Clinical practice. Long-QT syndrome. N Engl J Med 2008;358:169-76.
3.
go back to reference Jackman WM, Friday KJ, Anderson JL, Aliot EM, Clark M, Lazzara R. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis 1988;31:115-72. Jackman WM, Friday KJ, Anderson JL, Aliot EM, Clark M, Lazzara R. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc Dis 1988;31:115-72.
4.
go back to reference Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, Robinson JL, et al. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 2000;102:1178-85. Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, Robinson JL, et al. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 2000;102:1178-85.
5.
go back to reference Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 2001;103:89-95. Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation 2001;103:89-95.
6.
go back to reference Conrath CE, Jongbloed RJE, van Langen IM, van Tintelen, Hauer RNW, Robles de Medina EO, et al. Gene-specific distribution of cardiac events in LQTS1 and LQTS2. Neth Heart J 1999;6:254-9. Conrath CE, Jongbloed RJE, van Langen IM, van Tintelen, Hauer RNW, Robles de Medina EO, et al. Gene-specific distribution of cardiac events in LQTS1 and LQTS2. Neth Heart J 1999;6:254-9.
7.
go back to reference Wilde AA, Jongbloed RJ, Doevendans PA, Duren DR, Hauer RN, van Langen I, et al. Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1). J Am Coll Cardiol 1999;33:327-32. Wilde AA, Jongbloed RJ, Doevendans PA, Duren DR, Hauer RN, van Langen I, et al. Auditory stimuli as a trigger for arrhythmic events differentiate HERG-related (LQTS2) patients from KVLQT1-related patients (LQTS1). J Am Coll Cardiol 1999;33:327-32.
8.
go back to reference Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, et al. Long QT syndrome and pregnancy. J Am Coll Cardiol 2007;49:1092-8. Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, et al. Long QT syndrome and pregnancy. J Am Coll Cardiol 2007;49:1092-8.
9.
go back to reference Tan HL, Alings M, Van Olden RW, Wilde AA. Long-term (sub-acute) potassium treatment in congenital HERG-related long QT syndrome (LQTS2). J Cardiovasc Electrophysiol 1999;10:229-33. Tan HL, Alings M, Van Olden RW, Wilde AA. Long-term (sub-acute) potassium treatment in congenital HERG-related long QT syndrome (LQTS2). J Cardiovasc Electrophysiol 1999;10:229-33.
10.
go back to reference Rashba EJ, Zareba W, Moss AJ, Hall WJ, Robinson J, Locati EH, et al. Influence of pregnancy on the risk for cardiac events in patients with hereditary long QT syndrome. LQTS Investigators. Circulation 1998;97:451-6. Rashba EJ, Zareba W, Moss AJ, Hall WJ, Robinson J, Locati EH, et al. Influence of pregnancy on the risk for cardiac events in patients with hereditary long QT syndrome. LQTS Investigators. Circulation 1998;97:451-6.
Metagegevens
Titel
Pregnancy and the risk of torsades de pointes in congenital long-QT syndrome
Auteurs
P. G. Meregalli
I. C. D. Westendorp
H. L. Tan
P. Elsman
W. E. M. Kok
A. A. M. Wilde
Publicatiedatum
01-12-2008
Uitgeverij
Bohn Stafleu van Loghum
Gepubliceerd in
Netherlands Heart Journal / Uitgave 12/2008
Print ISSN: 1568-5888
Elektronisch ISSN: 1876-6250
DOI
https://doi.org/10.1007/BF03086191