This pilot study provides the first examination of sensory over-responsivity (SOR; exaggerated behavioral responses to sensory stimuli) in a clinical sample of youth with obsessive-compulsive disorder (OCD). Eighty treatment-seeking youth with OCD and their parents were recruited following initial assessment at a specialty outpatient treatment program. Procedures included clinician-administered diagnostic interviews and rating scales and parent-reported estimates of SOR and impairment. Findings suggest that SOR is relatively common among youth with OCD; 32.5 % experienced tactile hypersensitivity, 20.3 % experienced visual/auditory hypersensitivity, and 20.5 % experienced gustatory/olfactory hypersensitivity. Sensory over-responsivity was more common in younger children. Even after controlling for the effects of age and OCD symptom severity, youth with depressive disorder, ADHD, and disruptive behavior disorder comorbidities were more likely to have sensory hypersensitivity. Severity of compulsions, global OCD burden, and functional impairment were also moderately associated with the magnitude of SOR. Although preliminary, findings suggest SOR is relatively common among youth with OCD, especially preschool age youth. Further study is needed to understand the stability of SOR as well as its impact on treatment responsiveness.