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03-02-2021 | Original Article

Serum Galanin in Children with Autism Spectrum Disorder

Auteurs: Khaled Saad, Ahmed A. Abdel-Rahman, Abdulrahman A. Al-Atram, Alam-Eldin M. Abdallah, Amira Elhoufey, Eman M. Nagiub Abdelsalam, Dalia A. Nigm, Ola Elshora, Ahmad Roshdy Ahmad, Mohamed M. El-Tellawy, Khaled Hashim Mahmoud

Gepubliceerd in: Child Psychiatry & Human Development | Uitgave 2/2022

Abstract

Recent studies have attempted to measure several biomarkers to understand the complex interactions of the anatomic systems that may be involved in autism spectrum disorder (ASD). In CNS, galanin takes part in a variety of pathological and physiological processes. Prior research has indicated it is involved in several neuropsychiatric disorders and has a role in inhibiting the neuronal firing and release of serotonin, norepinephrine, and acetylcholine. To date, serum galanin levels have not been investigated in the context of ASD. This study aimed, therefore, to compare the serum galanin levels of children with ASD and healthy controls and to reveal any association between galanin level and the severity of ASD, as well as other psychological and demographic parameters. Serum galanin levels were measured by radioimmunoassay in 116 children with ASD and 98 healthy children. We observed significantly increased serum concentrations of galanin in children with ASD relative to healthy children. Moreover, children with severe ASD had significantly higher galanin levels than those with less severe disease. We also confirmed significant positive correlations between galanin and psychiatric parameters in children with ASD. For the first time, we suggest a possible correlation between serum galanin and the degree of ASD severity. Increased galanin levels may play a role in the pathogenesis of ASD.

vorige artikel Emergency Department Visits for Non-suicidal Self-harm, Suicidal Ideation, and Suicide Attempts in Children and Adolescents

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Titel: Serum Galanin in Children with Autism Spectrum Disorder
Auteurs: Khaled Saad
Ahmed A. Abdel-Rahman
Abdulrahman A. Al-Atram
Alam-Eldin M. Abdallah
Amira Elhoufey
Eman M. Nagiub Abdelsalam
Dalia A. Nigm
Ola Elshora
Ahmad Roshdy Ahmad
Mohamed M. El-Tellawy
Khaled Hashim Mahmoud
Publicatiedatum: 03-02-2021
Uitgeverij: Springer US
Gepubliceerd in: Child Psychiatry & Human Development / Uitgave 2/2022
Print ISSN: 0009-398X
Elektronisch ISSN: 1573-3327
DOI: https://doi.org/10.1007/s10578-021-01127-4

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Serum Galanin in Children with Autism Spectrum Disorder

Abstract

Andere artikelen Uitgave 2/2022

Association Between Exposure to Suicidal Behaviors and Suicide Attempts Among Adolescents: The Moderating Role of Prior Psychiatric Disorders

Internalizing Symptoms Among Youth in Foster Care: Prevalence and Associations with Exposure to Maltreatment

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The Positive Effect of the Rational Addiction Prevention Program (RAPP) on Adolescents with High Risk for Drug Consumption

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Association Between Exposure to Suicidal Behaviors and Suicide Attempts Among Adolescents: The Moderating Role of Prior Psychiatric Disorders

Internalizing Symptoms Among Youth in Foster Care: Prevalence and Associations with Exposure to Maltreatment

Emergency Department Visits for Non-suicidal Self-harm, Suicidal Ideation, and Suicide Attempts in Children and Adolescents

Understanding Phasic Irritability: Anger and Distress in Children’s Temper Outbursts

The Positive Effect of the Rational Addiction Prevention Program (RAPP) on Adolescents with High Risk for Drug Consumption

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