Introduction
According to major national treatment guidelines, cognitive-behavioral therapy (CBT) is the first-line treatment for obsessive–compulsive disorder (OCD), and it has shown its efficacy in numerous randomized-controlled trials (e.g., APA,
2007; DGPPN,
2022; NICE,
2005). CBT is continuously being developed further, and clinical interventions focusing on imagery rescripting (ImRs) are considered one promising route. Principally, ImRs aims at activating stressful mental images, and at changing them in the imagination in such a way that the resulting image is associated with more positive emotions (Ehring et al.,
2022). Developed from different theoretical backgrounds, and integrated, to a greater or lesser extent, within different therapy modalities such as schema therapy or acceptance and commitment therapy, the specific implementation of ImRs may differ (Cooper et al.,
2023; Ehring et al.,
2022).
ImRs was originally developed for posttraumatic stress disorder (PTSD), but has since been applied to other disorders (Strachan et al.,
2020). Concerning PTSD and anxiety disorders in general, and compared with passive control conditions using different study designs (from case series to randomized controlled trials, RCTs), ImRs has been described as efficacious (Morina et al.,
2017). However, the evidence base of ImRs still lags behind that of well-established interventions such as prolonged exposure, and thus, intensive research activities are currently being undertaken (Ehring et al.,
2022). This has resulted in more RCTs being conducted during the last few years, which have again yielded large effects of ImRs, compared with passive (mostly waitlist) control conditions (Kip et al.,
2023). When compared with active controls (such as prolonged/exposure or cognitive restructuring conditions), ImRs was equally effective (Kip et al.,
2023).
In line with the above, PTSD patients who had experienced childhood sexual abuse and persistently felt disgusted or contaminated as a result (
n = 17), benefited from mental imagery on skin or cell renewal within a CBT protocol, compared with a waitlist group (
n = 17), with large effects at one-month follow-up (Jung & Steil,
2013). A feasibility study also showed that this CBT protocol reduced OCD-related feelings of contamination and disgust (Fink-Lamotte et al.,
2023). In that sense, targeting mental images is not only therapeutically useful for PTSD. It is also promising in OCD treatment, as intrusive thoughts and images are a key symptom of the disorder (APA,
2022). According to an experimental investigation with
n = 30 patients diagnosed with contamination-related OCD and the same number of healthy controls, disgust that was induced visually was reduced almost as efficacious through ImRs as through cognitive reappraisal (Fink et al.,
2018) or active imagery controls (Fink-Lamotte et al.,
2022), and more than in a distraction control (Fink & Exner,
2019). Beyond disgust, mental contamination (i.e., feelings of internal dirtiness and pollution, caused by a person and that result in negative emotions, but without physical contact having occured) plays an important role, both in OCD patients and in healthy subjects, and can be evoked by thoughts, memories, images or statements (Fairbrother et al.,
2005; Radomsky et al.,
2018). The scenario used most often to induce mental contamination is imagining receiving a non-consensual kiss (De Putter,
2017; Fairbrother et al.,
2005).
During the last decade, only a handful of methodologically sound studies on ImRs were published with OCD patient groups (Kip et al.,
2023; Morina et al.,
2017). One of them followed a single-case experimental design, and included patients who described intrusive OCD-related imagery (Veale et al.,
2015). Whereas eight of the
n = 12 patients had reliably improved their OCD symptoms after one session of ImRs, only one of them had reliably improved after the control session. However, the control intervention was always delivered first, and eleven patients had had previous CBT for OCD, which is why carry-over effects cannot be ruled out. Another single case study was implemented with a group of
n = 18 OCD patients, and focused on guilt-inducing cognitions not necessarily related to the symptoms of OCD (Tenore et al.,
2020). Up to three months following three ImRs sessions, and especially in the first week, the authors found significantly reduced OCD symptoms in this group of patients. By contrast, Maloney et al. (
2019) included OCD patients with intrusive imagery in connection with individual symptom development (e.g., bullying, thoughts perceived as sexually inappropriate) who had not benefited sufficiently from previous CBT. Although OCD symptoms did not decrease after the control intervention (i.e., discussing the aversive memory), twelve of the
n = 13 participants had reliably improved their OCD symptomatology after one session of ImRs, and this effect was maintained at one-month follow-up. However, subsequent single case studies should take specific statistical features (e.g., the number of measurements available, autocorrelation) that follow from this specific design more directly into account (Manolov et al.,
2014).
Another sampling strategy that considers the resources available is that of using analogue participants. Analogue samples are valuable for investigating the mechanisms of different OCD treatments, and they often enable more precise experimental control (Abramowitz et al.,
2014). A current RCT compared
N = 198 participants (i.e., Amazon mTurk workers) with moderate OCD symptoms within three audio-guided groups: (1) ImRs on episodic future imagery, i.e., on a very unpleasant mental image of an individually relevant future OCD-related event, (2) imaginal exposure and (3) imagining an everyday activity (Cooper et al.,
2023). In order to investigate the interventions on a low-threshold basis, the participants did not receive therapist support, but implemented the conditions in an online self-guided format. ImRs participants reported greater reductions, both in anxiety and fear, than those in the exposure group, whose values changed less than in the other two groups. Although participants in the ImRs condition reported greater reductions in disgust than participants in the exposure condition, there was no evidence of differences between the ImRs and control conditions on disgust (Cooper et al.,
2023).
Despite a growing number of investigations on the efficacy of ImRs in OCD during the last few years, there is still a paucity of RCTs including different control groups. First of all, we investigated whether a newly developed
spit-face scenario induced disgust and anxiety in the participants, i.e., analogue subjects reporting at least mild obsessive–compulsive (OC) symptoms. The
spit-face scenario is an adaptation of the non-consensual-kiss paradigm (Millar et al.,
2023). In the adapted version, subjects are confronted with an unpleasant smelling stranger who spits at them when he speaks (see Procedure). It was hypothesized that the
spit-face scenario would induce disgust and anxiety (H1).
The objective of the randomized controlled study was then to investigate if there was lower disgust and anxiety in participants after an ImRs manipulation than in two control conditions (i.e., imagery focus, distraction). It was hypothesized that compared to those assigned to a control condition, participants assigned to ImRs would demonstrate a greater reduction in disgust and anxiety across sessions (H2).
Discussion
The present study investigated disgust and anxiety using a newly developed audio imagery that should be applicable regardless of the participants’ gender, and without the notion of a forced kiss, the spit-face scenario. Presented online and via audio, we then examined whether an ImRs manipulation reduced disgust and anxiety in subjects with obsessive–compulsive symptoms compared to two control conditions (i.e., imagery focus and distraction). First of all, the spit-face scenario induced feelings of disgust, comparable with watching a disgusting film, and with large effect sizes. Although anxiety was evoked as well, these effect sizes were significantly smaller, i.e., in the small to medium range. Around 70 to 79% of the participants were able to visualize the scenario vividly and follow the instructions well (Supplement 1). Altogether, the results support the assumption of validity of the spit-face scenario and its use in future studies. They are also needed to independently investigate the validity of the spit-face scenario, also at a greater temporal distance from the Covid pandemic.
Secondly, ImRs contributed significantly to a reduction of disgust. However, a psychoeducational audio reduced disgust equally, and except for VAS anxiety, subjects in the ImRs and distraction conditions reported quite similar patterns (Fig.
2). A major characteristic of ImRs is its strong experience activation (Ehring et al.,
2022; Saulsman et al.,
2019), but a similar reduction may indicate different underlying mechanisms. Altogether, our results underline the importance of choosing active control groups, which nevertheless do not contain the ImRs ingredient (Cooper et al.,
2023). Furthermore, the results are in line with meta-analytical results, according to which, in comparison with active control groups, the effects of ImRs were very small to non-significant (Kip et al.,
2023; Kroener et al.,
2023).
Despite the instruction not to distract themselves, 13% of the participants reported having done so. They stated having been distracted for example by their mobile phone or their thoughts, or having avoided negative feelings by cleaning their desk or shaking hands, among others (Supplement 2). Considering again the result that participants in the psychoeducation condition indicated substantial relief, distraction was used to avoid negative feelings. While avoidance seemed less relevant in imagery focus, participants did not benefit from this manipulation, which indicates that its instruction should be changed, prolonged or repeated to enable habituation or inhibitory learning (Cooper et al.,
2023). Moreover, future studies should include a more informative active control group, such as cognitive reappraisal, that was shown to reduce fear and disgust in the short-term in experimental settings (Olatunji et al.,
2017; Shurick et al.,
2012).
As distraction was a possible confounder in similar studies as well (Cooper et al.,
2023), future study protocols could benefit from proactively instructing subjects on how to deal with distraction (e.g., to return to the intervention whenever thoughts wander) for all study groups. The importance of therapist-led training in the use of an audio intervention, and also in filling out questionnaire items, is supported by the remark of one participant at the end of the study: “For example, I had a different feeling when answering the questions than when listening to the audio. I very quickly got away from the feeling of the audio recordings and always had a very neutral feeling when answering questions, as I no longer related the questions to the audio recordings, but to the feeling afterwards” (P1607). As evidence from internet and mobile interventions shows, human support and guidance may reduce attrition and increase the effect of such interventions (Ebert et al.,
2018). We thus assume that a certain level of clinical guidance could support participants in becoming less distracted and focusing more on the manipulation in a future study. From a clinical point of view, using online ImRs could supplement face-to-face CBT, for example as homework between weekly sessions (Cooper et al.,
2023).
In our study, some limitations must be taken into account. Whereas the sample age ranged from 18 to 72 years, the vast majority was in young adulthood, female and students. Ethnicity was not surveyed. Although obsessive–compulsive symptom burden was present in our sample (e.g., moderate symptoms on the OCI-R, 26.9% with previous OCD diagnosis, 48.4% with previous psychotherapy), diagnoses were not confirmed by independent clinicians or by using a validated clinical interview. Therefore, future studies should include persons from more diverse ages, gender and ethnic backgrounds, and most notably, patients who received independent diagnostic interviews. Moreover, despite randomization, the Imagery focus group was smaller than the other study groups due to differential dropout. However, our study was among the first to investigate the differential effects of online self-administered imagery, highlighting both the feasibility as well as the challenges of those studies (Cooper et al.,
2023). Using randomization and including active controls was methodologically stringent, but also associated with implementation challenges. Concluding from some open answers of our participants, systematically examining and comparing the negative effects of different interventions (Schulz et al.,
2011) should be an important feature of subsequent online experiments, especially before their widespread use with patient groups.
The current expanded use of ImRs from PTSD and personality disorders to a broad spectrum of mental disorders also goes hand in hand with the need for RCTs that address the necessary vs. sufficient elements on the one hand, and the common vs. distinct mechanisms of change of effective ImRs on the other (Saulsman et al.,
2019; Strachan et al.,
2020). In one such study, mastery-based ImRs reduced anxiety (but not disgust) associated with episodic future images more than attachment-based rescripting, whereas no significant effects emerged if the target imagery was a mere memory (Cooper et al.,
2024). Further studies of this kind are needed to adapt the manipulation to individual problematic areas. As “mental imagery can be both a problematic contributor to psychopathology and a potentially powerful tool for intervention” (p. 242), imagery techniques were conceptualized as a central component of CBT from the beginning, and have been returned to the focus of clinicians and researchers during the last decade (Saulsman et al.,
2019). We advocate for further ImRs studies, especially in so-far under-researched fields such as OCD treatments.
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