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Quality of Life Research
Gepubliceerd in:

06-11-2024

Symptom prevalence in patients with advanced heart failure and its association with quality of life and activities of daily living

Auteurs: Moritz Blum, Karen McKendrick, Laura P. Gelfman, Nathan E. Goldstein

Gepubliceerd in: Quality of Life Research | Uitgave 2/2025

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Abstract

Background

Quality of life (QOL) and functional status are two key outcomes for patients with advanced heart failure (HF). We examined the association of eleven symptoms with QOL and functional status impairment in patients with advanced HF.

Methods and results

This was a retrospective analysis of baseline data from a multi-center, cluster-randomized controlled trial (NCT01459744) which enrolled patients with an implanted cardioverter-defibrillator and advanced HF at high-risk for mortality. Study instruments included the Condensed Memorial Symptom Assessment Scale, the Kansas City Cardiomyopathy Questionnaire QOL subscale, and the number of activities of daily living (ADL) patients had difficulties with. The study included 413 subjects. In generalized linear models which were adjusted for baseline characteristics, the total number of symptoms was significantly associated with worse QOL, as was the presence of each individual symptom, except constipation. Lack of energy demonstrated the strongest negative association with QOL. Similarly, the total number of symptoms was associated with a higher number of ADL difficulties (i.e., worse functional status). The presence of pain, lack of energy and drowsiness was individually associated with more ADL difficulties.

Conclusion

Among patients with advanced HF, a higher number of symptoms and specific individual symptoms were associated with worse QOL and functional status.
vorige artikel Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure
volgende artikel Identification of meaningful individual-level change thresholds for worsening on the patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE®)
Bijlagen
Alleen toegankelijk voor geautoriseerde gebruikers
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Metagegevens
Titel
Symptom prevalence in patients with advanced heart failure and its association with quality of life and activities of daily living
Auteurs
Moritz Blum
Karen McKendrick
Laura P. Gelfman
Nathan E. Goldstein
Publicatiedatum
06-11-2024
Uitgeverij
Springer New York
Gepubliceerd in
Quality of Life Research / Uitgave 2/2025
Print ISSN: 0962-9343
Elektronisch ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-024-03823-9

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