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Research on Child and Adolescent Psychopathology
Gepubliceerd in:

01-05-2012

Youth Appraisals of Inter-parental Conflict and Genetic and Environmental Contributions to Attention-Deficit Hyperactivity Disorder: Examination of GxE Effects in a Twin Sample

Auteurs: Molly Nikolas, Kelly L. Klump, S. Alexandra Burt

Gepubliceerd in: Research on Child and Adolescent Psychopathology | Uitgave 4/2012

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Abstract

Identification of gene x environment interactions (GxE) for attention-deficit hyperactivity disorder (ADHD) is a crucial component to understanding the mechanisms underpinning the disorder, as prior work indicates large genetic influences and numerous environmental risk factors. Building on prior research, children’s appraisals of self-blame were examined as a psychosocial moderator of latent etiological influences on ADHD via biometric twin models, which provide an omnibus test of GxE while managing the potential confound of gene-environment correlation. Participants were 246 twin pairs (total n = 492) ages 6–16 years. ADHD behaviors were assessed via mother report on the Child Behavior Checklist. To assess level of self-blame, each twin completed the Children’s Perception of Inter-parental Conflict scale. Two biometric GxE models were fit to the data. The first model revealed a significant decrease in genetic effects and a significant increase in unique environmental influences on ADHD with increasing levels of self-blame. These results generally persisted even after controlling for confounding effects due to gene-environment correlation in the second model. Results suggest that appraisals of self-blame in relation to inter-parental conflict may act as a key moderator of etiological contributions to ADHD.
vorige artikel Aggression Among Children with ADHD, Anxiety, or Co-occurring Symptoms: Competing Exacerbation and Attenuation Hypotheses
volgende artikel Evidence for a General ADHD Factor from a Longitudinal General School Population Study
Voetnoten
1
Model fitting was examined using two additional data preparation strategies when parsing the CPIC self-blame scores (e.g., dichotomous, quartiles). In both cases, the same pattern of results emerged, indicating that findings are robust to data preparation strategy.
 
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Metagegevens
Titel
Youth Appraisals of Inter-parental Conflict and Genetic and Environmental Contributions to Attention-Deficit Hyperactivity Disorder: Examination of GxE Effects in a Twin Sample
Auteurs
Molly Nikolas
Kelly L. Klump
S. Alexandra Burt
Publicatiedatum
01-05-2012
Uitgeverij
Springer US
Gepubliceerd in
Research on Child and Adolescent Psychopathology / Uitgave 4/2012
Print ISSN: 2730-7166
Elektronisch ISSN: 2730-7174
DOI
https://doi.org/10.1007/s10802-011-9583-6

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